The TYMS gene encodes thymidylate synthase, a crucial enzyme involved in the synthesis of thymidine, one of the four nucleotides essential for DNA replication and repair. This enzyme depends on active folate (5,10-methylene-THF) to function effectively, closely linking TYMS to folate metabolism. Variants in the TYMS gene can influence folate availability at the cellular level and may modify the body's response to folate or folate-based treatments. Such alterations may contribute to impaired DNA synthesis, increased vulnerability to certain diseases, or varied responses to chemotherapy or supplementation.
TYMS encodes thymidylate synthase, an enzyme essential for the production of thymidine, which is used in DNA synthesis and repair.
The enzyme utilises active folate as a cofactor, so folate status significantly affects TYMS activity.
Certain variants can decrease enzyme efficiency, affecting DNA replication and folate metabolism.
Yes, they can affect vulnerability to disease or the effectiveness of folate-related treatments, including specific chemotherapy drugs.