Zonulin
Zonulin is a protein that regulates the permeability of tight junctions between cells in the digestive tract. It plays a crucial role in the intestinal barrier, controlling the passage of substances, including nutrients and antigens, between the gut and the bloodstream. Imbalances in zonulin levels can affect gut permeability, potentially leading to various health issues....
Description
Leaky gut, or increased intestinal permeability, is a condition where the lining of the small intestine becomes damaged, allowing undigested food particles, toxic waste products, and bacteria to “leak” through the intestines into the bloodstream. Zonulin is a key regulator of this intestinal permeability. When zonulin levels are high, it can lead to the loosening of the tight junctions, contributing to leaky gut.
Individuals with gastrointestinal symptoms, autoimmune disorders, or food sensitivities could benefit from testing their zonulin levels. Understanding zonulin levels can provide insights into gut permeability issues and help in diagnosing conditions like leaky gut. It’s also useful for those with chronic inflammatory diseases or allergies, as zonulin plays a role in gut health and the immune response.
Leaky gut can cause various symptoms, including gastrointestinal issues like bloating, gas, diarrhea, or irritable bowel syndrome (IBS). It’s also associated with systemic symptoms such as fatigue, headaches, skin problems like eczema or acne, joint pain, and immune system reactions. These symptoms can stem from the inflammation and imbalance caused by foreign substances entering the bloodstream through the compromised intestinal barrier.
Gluten can stimulate the release of zonulin in individuals, particularly those with celiac disease or gluten sensitivity. This increase in zonulin levels leads to the loosening of the tight junctions in the intestinal wall, contributing to increased gut permeability or leaky gut. This process is a key factor in the onset of symptoms and inflammatory responses associated with gluten sensitivity.
Tests containing this item
The Gut Microbiome Test XL is for those who really want to understand their health. Whether you have IBS/IBD, stomach issues like Crohn’s disease or ulcerative colitis, weight problems, diseases such as Parkinson’s or Alzheimer’s, depression, or other diffuse problems with no apparent cause, this test can provide answers to any gut imbalances you may have. It is our most comprehensive and best-selling gut health test.
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GetTested’s Leaky Gut Test measures zonulin levels, which, when excessive, are linked to leaky gut syndrome. This condition allows particles like undigested food, toxins, and microbes to penetrate the intestinal barrier and enter the bloodstream. Such breaches can disrupt the immune system, increase bodily inflammation, and potentially lead to various diseases.
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The GI Advanced Microbiome Profile from GetTested is a highly detailed stool test that analyzes over 120 markers across 15 categories to provide a thorough assessment of your gut health. This test includes measurements for gut permeability, antimicrobial sensitivities, and key bacteria like Helicobacter pylori. It’s ideal for individuals experiencing chronic digestive issues or seeking a more comprehensive evaluation of their microbiome and overall digestive function.
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The Microbiome Profile Test (Medium) from GetTested offers a comprehensive analysis of your gut health by testing over 114 markers, including gut bacteria, parasites, fungi, pathogens, and more. This advanced test is perfect for individuals experiencing digestive issues or those looking for detailed insights into their microbiome. With state-of-the-art DNA-based technology, the Microbiome Profile Test provides reliable results to help you optimize your digestive health.
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