Anti-Deamidated Gliadin Antibodies (IgA & IgG)
Anti-deamidated gliadin antibodies (anti-DGP) are immune proteins produced in response to deamidated fragments of gliadin, a component of gluten. These antibodies, especially when both IgA and IgG subtypes are measured, provide high sensitivity and specificity for detecting celiac disease. Elevated levels indicate an immune response to gluten, often before intestinal damage becomes apparent. Testing for anti-DGP is particularly useful in individuals with suspected celiac disease, including those who have been on a gluten-free diet for a short time. Measuring both IgA and IgG allows for better detection across different immune profiles.
Description
People experiencing symptoms like chronic diarrhea, stomach pain, weight loss, fatigue, or skin rashes who suspect gluten sensitivity or celiac disease may benefit from this test. It is also beneficial for those with a family history of celiac disease.
Yes, in some cases, individuals with celiac disease may not exhibit any noticeable symptoms but can still present elevated anti-DGP levels, indicating silent or latent celiac disease.
Yes, although rare, false positives or negatives can occur, especially if the individual has already been on a strict gluten-free diet for a prolonged period, which may reduce antibody levels.
