Hippuric Acid
Hippuric acid is a metabolic compound formed in the liver from the conjugation of benzoic acid with glycine. It reflects both detoxification capacity and microbial activity in the gut. Elevated levels may indicate increased microbial fermentation, exposure to certain food additives, or an active detoxification response. Low concentrations can be seen with reduced liver conjugation capacity or low microbial production of precursors.
Description
Elevated hippuric acid may indicate increased microbial fermentation, exposure to food additives (such as benzoates), or an active detoxification response. Low levels can result from reduced liver conjugation capacity or insufficient microbial production of precursors.
Testing hippuric acid can be beneficial for individuals showing signs of liver overload, chemical sensitivity, or digestive imbalance. It can also assist in assessing detoxification efficiency and microbial activity in the gut.
Levels are influenced by both gut microbial metabolism and liver conjugation processes. Diet, toxin exposure, microbial composition, and nutrient availability (particularly glycine) all play key roles in determining hippuric acid concentration.
Yes. Supporting liver detoxification with proper hydration, antioxidants, and adequate glycine and B vitamins can help promote healthy conjugation. Maintaining gut microbial balance through fibre-rich foods and reducing exposure to artificial additives also supports optimal levels.
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