Nectarines, juicy and sweet stone fruits closely related to peaches, are enjoyed by many. However, some individuals may experience nectarine intolerance, impacting their ability to digest this fruit without discomfort....

Nutmeg, a spice known for its warm, nutty flavor, is commonly used in baking and cooking. While it enhances the flavor of various dishes, some individuals may experience nutmeg intolerance, affecting their ability to digest it comfortably....

Oats intolerance is a condition where individuals have difficulty digesting oats, leading to gastrointestinal discomfort. This intolerance differs from an oats allergy, which involves an immune system response and can cause more severe reactions. People with oats intolerance typically experience digestive symptoms after consuming oats or oat-based products....

Octopus intolerance refers to adverse reactions or symptoms that some individuals may experience after consuming octopus seafood. It is distinct from octopus allergies as it does not involve the immune system's response to specific proteins but is related to difficulties in digesting certain components in octopus....

Onion intolerance is a condition where the body has difficulty digesting onions, leading to gastrointestinal discomfort. This intolerance differs from an onion allergy, which involves an immune system response and can cause more severe reactions. Onion intolerance typically results in digestive symptoms following the consumption of onions....

FANCI (FA Complementation Group I): FANCI is part of the Fanconi anemia (FA) pathway, crucial for DNA repair. It plays a role in the response to DNA damage and is important for maintaining genomic stability. Mutations in FANCI can cause Fanconi anemia, a disorder characterized by bone marrow failure, cancer susceptibility, and developmental abnormalities....

Orange allergy is an immune response to certain proteins found in oranges. While less common than some other food allergies, it can cause adverse reactions in sensitive individuals. Reactions can range from mild oral allergy symptoms to more severe systemic effects, and they can occur from both eating oranges and exposure to orange peel or juice....

FAP (Fibroblast Activation Protein Alpha): FAP encodes an enzyme known as fibroblast activation protein alpha, which is expressed by activated fibroblasts in the tumor microenvironment. It plays a role in tissue remodeling and is a potential therapeutic target in cancer treatment....

FAR1 (Fatty Acyl-CoA Reductase 1): FAR1 is involved in the synthesis of fatty alcohols from fatty acyl-CoA substrates, a key step in the production of wax esters and other complex lipids. These lipids are essential components of cell membranes and are involved in protecting cells against environmental stress. FAR1's role in lipid metabolism has implications for skin barrier function, lipid storage diseases, and the development of biofuels and industrial chemicals....

FARP2 (FERM, ARH/RhoGEF, And Pleckstrin Domain Protein 2): FARP2 is a signaling protein that influences neuronal development and synaptic plasticity by regulating dendritic spine formation and actin cytoskeleton remodeling. It acts as a guanine nucleotide exchange factor for small GTPases, mediating cell signaling pathways that affect neuronal connectivity and function. Alterations in FARP2 expression or function are associated with neurological disorders, highlighting its significance in brain development and synaptic regulation....

FARSA (Phenylalanyl-tRNA Synthetase Subunit Alpha): FARSA is involved in the translation process of protein synthesis, specifically in attaching phenylalanine to its corresponding tRNA. This function is essential for the accurate translation of mRNA into proteins. Mutations in FARSA or dysregulation of its activity can lead to errors in protein synthesis, potentially causing a range of cellular dysfunctions and contributing to disease processes....

Ostrich meat, known for its lean quality and flavor similar to beef, is a less common but increasingly popular alternative to traditional meats. However, some individuals may experience ostrich intolerance, impacting their ability to digest this meat without discomfort....

Oyster intolerance refers to adverse reactions or symptoms that some individuals may experience after consuming oysters. It differs from oyster allergies as it does not involve the immune system's response to specific proteins but is related to difficulties in digesting certain components in oysters....

Oyster mushroom intolerance is a condition where individuals experience difficulty digesting oyster mushrooms, a type of edible mushroom commonly used in cooking. This can lead to gastrointestinal discomfort. Oyster mushroom intolerance differs from an oyster mushroom allergy, which involves an immune system response and can cause more severe reactions. People with oyster mushroom intolerance typically experience digestive symptoms after consuming oyster mushrooms or dishes containing them....

FBH1 (F-Box DNA Helicase 1): FBH1, also known as FBD4, encodes a DNA helicase involved in DNA repair and replication. It plays a role in maintaining genomic stability and preventing DNA damage accumulation. Dysfunctions in FBH1 can lead to genomic instability, a hallmark of cancer, making it important in cancer biology and the study of DNA repair mechanisms....

Papaya, a tropical fruit known for its vibrant orange flesh and sweet flavor, is a popular choice for many. However, some individuals may experience papaya intolerance, impacting their ability to digest this fruit without discomfort....

FBLL1 (Fibroblast-Like Protein 1): FBLL1, a member of the fibroblast-like protein family, serves as a pivotal player in orchestrating cellular interactions within the extracellular matrix (ECM). Through its regulatory functions, FBLL1 exerts a profound influence on diverse physiological processes, encompassing tissue regeneration, vascular development, and embryogenesis, by modulating ECM composition and architecture. The finely tuned activity of FBLL1 is indispensable for the maintenance of tissue homeostasis and repair mechanisms. However, aberrant expression or dysregulation of FBLL1 has been implicated in the pathogenesis of several disorders, including cancer progression, tissue fibrosis, and inflammatory conditions. Understanding the intricate control of FBLL1 activity...

FBLN5 (Fibulin 5): FBLN5 is involved in elastic fiber assembly and connective tissue organization, playing a crucial role in maintaining the integrity and elasticity of extracellular matrix. It is essential for skin, vascular, and lung function. Dysregulation of FBLN5 is associated with tissue stiffness, age-related macular degeneration, and organ fibrosis, highlighting its importance in tissue remodeling and disease....

FBXO24 (F-Box Protein 24): FBXO24 is part of the F-box protein family, which plays a role in protein degradation via the ubiquitin-proteasome system. It is involved in cell cycle regulation and protein turnover, but its specific physiological functions and implications in diseases are not fully elucidated....

Parmesan cheese, a popular Italian cheese known for its savory and nutty flavor, is a key ingredient in various dishes. However, some individuals may experience Parmesan cheese intolerance, impacting their ability to digest this cheese without discomfort....

Parsley, a versatile herb used for its fresh and vibrant flavor, is a common ingredient in various cuisines. However, some individuals may experience parsley intolerance, impacting their ability to consume this herb without discomfort....

FBXO8 (F-Box Protein 8): FBXO8 is part of the F-box family of proteins, which play critical roles in the ubiquitin-proteasome pathway, a system crucial for protein degradation and turnover in cells. As an F-box protein, FBXO8 is likely involved in targeting specific proteins for degradation, thereby regulating various cellular processes including cell cycle, signal transduction, and immune responses. The exact substrates and physiological functions of FBXO8 are not fully understood, but its involvement in protein degradation suggests its potential impact on cellular homeostasis and disease states, particularly in conditions where protein aggregation or misfolding is a concern, such as neurodegenerative...

FCER1A (High Affinity Immunoglobulin E Receptor Subunit Alpha): FCER1A is crucial in allergic reactions, binding to immunoglobulin E (IgE) and activating mast cells and basophils. This activation releases histamine and other mediators of inflammation, leading to allergic symptoms. FCER1A's role in allergies and asthma makes it a focal point for developing treatments that mitigate allergic responses....

Pecans, delicious nuts known for their rich and buttery flavor, are a popular ingredient in various recipes and snacks. However, some individuals may experience pecan nut intolerance, impacting their ability to consume pecans without discomfort....

Peppermint, a fragrant herb known for its refreshing flavor and potential health benefits, is commonly used in teas, candies, and culinary dishes. However, some individuals may experience peppermint intolerance, impacting their ability to consume peppermint without discomfort....

FCER1G (Fc Epsilon Receptor I Gamma): FCER1G is an important component of the high affinity receptor for the Fc region of immunoglobulin E (IgE). It plays a critical role in allergic responses and is involved in the activation of mast cells and basophils. Alterations in this gene can influence the severity and susceptibility to allergic diseases and asthma....

SETBP1 (SET Binding Protein 1): SETBP1 is a protein that interacts with SET, a regulator of histone acetylation and chromatin remodeling. SETBP1 plays a role in gene regulation and has been associated with developmental disorders and leukemia....

Perch intolerance is a non-allergic adverse reaction to perch, a freshwater fish known for its mild and delicate flavor. Unlike perch allergies, which involve the immune system's response to allergens, intolerance to perch typically relates to difficulties in digesting specific proteins or substances in the fish....

FCGR3A (Fc Fragment Of IgG Receptor IIIa): FCGR3A, also known as CD16a, is a receptor for the Fc portion of immunoglobulin G (IgG) and plays a key role in immune response by mediating antibody-dependent cellular cytotoxicity (ADCC). It is expressed on natural killer (NK) cells, macrophages, and some T cells, facilitating the clearance of pathogens and antibody-coated cells. Variations in FCGR3A have been associated with susceptibility to autoimmune diseases and response to immunotherapy in cancer treatment....

FCHO2 (FCH Domain Only 2): FCHO2 is involved in the process of clathrin-mediated endocytosis, a key mechanism for internalizing substances from the cell surface. It plays a role in vesicle formation and trafficking within cells. Dysregulation of FCHO2 can affect cellular uptake processes and has potential implications in various cellular dysfunctions....

Persimmons, sweet and flavorful fruits known for their vibrant orange color, are enjoyed in various culinary dishes and as a fresh snack. However, some individuals may experience persimmon intolerance, impacting their ability to digest this fruit without discomfort....

SETD7 (SET Domain Containing 7, Lysine Methyltransferase): SETD7 is involved in epigenetic regulation as it encodes an enzyme responsible for methylation of histone proteins. This methylation is crucial for regulating gene expression. Dysregulation of SETD7 activity is associated with various pathological conditions, including cancer and cardiovascular diseases....

SFTPA1 (Surfactant Protein A1): SFTPA1 encodes a protein crucial in lung function, particularly in the innate immune response of the respiratory tract. It helps in reducing surface tension in the lungs and plays a role in defending against respiratory pathogens. Mutations in SFTPA1 are associated with respiratory diseases....

FCHSD2 (FCH And Double SH3 Domains 2): FCHSD2 is involved in cellular processes like endocytosis and cytoskeletal organization. It's notable for its role in vesicle transport and has been linked to certain cancers. Its function in cell signaling and membrane dynamics makes it relevant in understanding cellular communication and disease mechanisms....

Pike, a freshwater fish known for its mild flavor and versatility in cooking, is enjoyed by many seafood enthusiasts. However, some individuals may experience pike fish intolerance, impacting their ability to digest this fish without discomfort. ...

FBXL17 (F-Box and Leucine-Rich Repeat Protein 17): FBXL17 is a member of the F-box protein family, which are critical components of the SCF (SKP1-cullin-F-box) complex, responsible for the ubiquitination and subsequent proteasomal degradation of target proteins. Through its role in protein turnover, FBXL17 regulates various cellular processes including cell cycle progression, signal transduction, and transcription. Its specific function involves the recognition and binding of phosphorylated substrates via its F-box motif and leucine-rich repeats, targeting them for ubiquitination. The precise regulation of protein levels by FBXL17 is essential for maintaining cellular homeostasis and function. Dysregulation of FBXL17 activity has been linked...

FBXO21 (F-Box Protein 21): FBXO21 is part of the F-box protein family, key components in the ubiquitin-proteasome system, which regulates protein degradation. This gene plays a crucial role in various cellular processes, including cell cycle regulation and signal transduction. Dysregulation of FBXO21 can lead to disorders in protein homeostasis, making it significant in the study of diseases where protein turnover is disrupted, such as neurodegenerative diseases and cancers....

FCRL3 (Fc Receptor-Like 3): FCRL3 is a member of the Fc receptor-like (FCRL) gene family and is primarily expressed in B cells. It is involved in modulating B cell receptor signaling and antibody production. FCRL3 may play a role in regulating immune responses and autoimmune diseases....

Passion fruit, known for its unique flavor and aromatic qualities, is a tropical fruit enjoyed in various culinary applications. However, some individuals may experience passion fruit intolerance, affecting their ability to digest this fruit without discomfort....

Stone fruit that can cause allergies ranging from oral allergy syndrome to severe reactions like anaphylaxis.

FCRL6 (Fc Receptor-Like 6): FCRL6 is involved in the immune system's regulation, expressed on certain T cells and natural killer (NK) cells. It plays a role in modulating immune responses, potentially influencing the activity of these cells in infection, autoimmune diseases, and cancer. The study of FCRL6 aims to uncover novel therapeutic targets for enhancing immune regulation....

Peach allergy is an immune system response to proteins found in peaches, a condition more commonly observed in people with tree pollen allergies due to cross-reactivity. This type of allergy can vary from mild oral allergy symptoms to more severe, potentially life-threatening reactions like anaphylaxis....

Peanut allergy is one of the most common food allergies, particularly in children, and involves an overreaction of the immune system to proteins found in peanuts. Unlike tree nut allergies, peanut allergy is to a legume, not a true nut. This allergy can range from mild reactions to severe, potentially life-threatening conditions like anaphylaxis....

SGCD (Sarcoglycan Delta): SGCD is part of the dystrophin-glycoprotein complex, crucial for muscle integrity and function. Mutations in SGCD are associated with limb-girdle muscular dystrophy, a group of genetic disorders that weaken and waste the muscles around the hips and shoulders....

Pears, sweet and juicy fruits enjoyed for their delicious taste and nutritional benefits, are a popular choice for many. However, some individuals may experience pear intolerance, impacting their ability to digest this fruit without discomfort....

FDX1 (Ferredoxin 1): FDX1 plays a crucial role in mitochondrial electron transport, facilitating the transfer of electrons in various metabolic processes, including steroid hormone biosynthesis and detoxification reactions. It is a key component in the synthesis of iron-sulfur clusters, essential cofactors for many enzymes. Dysregulation of FDX1 has implications for energy metabolism and has been explored in the context of diseases related to mitochondrial function....

SGK1 (Serum/Glucocorticoid Regulated Kinase 1): SGK1 is a serine/threonine kinase regulated by glucocorticoids and involved in cell survival, ion transport, and metabolic processes. It plays a role in responding to stress and in the regulation of ion channels, particularly in the kidneys, affecting sodium and water balance. Dysregulation of SGK1 has implications in hypertension, diabetic nephropathy, and could contribute to the development of certain cancers....

SH2B3 (SH2B Adaptor Protein 3): SH2B3, also known as LNK, is an adaptor protein that negatively regulates cytokine signaling in hematopoietic cells. It plays a crucial role in maintaining hematopoietic stem cell homeostasis and regulating immune responses. SH2B3 mutations are associated with a variety of hematologic disorders, including myeloproliferative neoplasms and autoimmune diseases, underscoring its importance in blood cell development and immune regulation....

FERD3L (Fer3-Like BHLH Transcription Factor): FERD3L is a transcription factor with potential roles in neuronal development and differentiation. Its exact functions are still being elucidated, but it may be involved in neurodevelopmental processes....

FGF5 (Fibroblast Growth Factor 5): FGF5 is a member of the fibroblast growth factor family, a group of proteins known for their roles in cellular proliferation, differentiation, and signaling. As a key mediator of biological processes, FGF5 is involved in the regulation of hair growth cycles, and its activity has been linked to influencing hair length in various species. Beyond its role in hair follicle regulation, FGF5 contributes to the development and repair of tissues, including the nervous system, where it plays a role in neural development. Dysregulation of FGF5 has been implicated in certain pathological conditions, such as cancer,...

Pike-perch, also known as zander, is a popular freshwater fish enjoyed for its mild and delicate flavor. However, some individuals may experience pike-perch intolerance, impacting their ability to digest this fish without discomfort....

SH3PXD2A (SH3 And PX Domains 2A, also known as TKS5): SH3PXD2A is a scaffold protein involved in the formation of podosomes or invadopodia in cells, structures associated with tissue remodeling, cell migration, and invasion. It plays a significant role in cancer metastasis and angiogenesis by facilitating the degradation of the extracellular matrix. SH3PXD2A's function in cellular dynamics and interaction with the environment makes it a potential target for cancer therapy, particularly in limiting cancer spread....

FGFR2 (Fibroblast Growth Factor Receptor 2): FGFR2 is a receptor for fibroblast growth factors and is involved in numerous processes including cell growth, differentiation, and repair. Mutations in FGFR2 are associated with various developmental disorders, including craniosynostosis and skeletal dysplasia, and are implicated in certain types of cancer....

FFAR4 (Free Fatty Acid Receptor 4): FFAR4, also known as GPR120, is a receptor for omega-3 fatty acids and plays a significant role in metabolic regulation and inflammatory processes. It is involved in the regulation of insulin sensitivity, anti-inflammatory responses, and appetite control. Research suggests that FFAR4 is a potential therapeutic target for metabolic disorders like obesity and type 2 diabetes....

Pineapple intolerance refers to adverse reactions or symptoms that some individuals may experience after consuming pineapple fruit. It differs from pineapple allergies as it does not involve the immune system's response to specific proteins but is related to difficulties in digesting certain components in pineapple....

SGMS1 (Sphingomyelin Synthase 1): SGMS1 is involved in sphingolipid metabolism, which is crucial for cell membrane integrity and signaling. It plays a role in the conversion of ceramide to sphingomyelin, important in cell signaling and apoptosis. Dysregulation of SGMS1 has implications in metabolic and neurodegenerative diseases....

SH3YL1 (SH3 And SYLF Domain Containing 1): SH3YL1 is a gene that encodes a protein containing SH3 (Src homology 3) and SYLF domains, suggesting a role in protein-protein interactions. The specific function of SH3YL1 is still under investigation, but it may be involved in cellular signaling pathways and membrane dynamics....

SH2B1 (SH2B Adaptor Protein 1): SH2B1 is a key adaptor protein that supports various intracellular signaling pathways, especially those related to insulin and leptin. It's important for energy balance, body weight regulation, and glucose metabolism. Genetic variants of SH2B1 are associated with obesity and insulin resistance....

FGGY (FGGY Carbohydrate Kinase Domain Containing): FGGY is a carbohydrate kinase involved in carbohydrate metabolism. Its exact role and functions are not fully elucidated, but carbohydrate kinases are known to be important in energy metabolism and may play roles in metabolic disorders....

FGD4 (FYVE, RhoGEF, and PH Domain Containing 4): FGD4 encodes a guanine nucleotide exchange factor that specifically activates Cdc42, a member of the Rho family of GTPases. This activation plays a key role in regulating cytoskeletal organization, cell shape, and migration. Mutations in FGD4 are associated with Charcot-Marie-Tooth disease, a disorder affecting peripheral nerves, highlighting its importance in nerve development and function....

SHC1 (SHC Adaptor Protein 1): SHC1 is an adaptor protein involved in the signal transduction pathways that regulate cell growth, differentiation, and survival. By mediating the activation of the Ras/MAPK signaling pathway, SHC1 influences cellular responses to growth factors and cytokines. Dysregulation of SHC1 has been implicated in the development of various cancers, as well as in cardiovascular diseases, highlighting its critical role in cellular signaling and disease pathogenesis....

FGF10 (Fibroblast Growth Factor 10): FGF10 is critical in embryonic development, particularly in limb and lung development. It's involved in the proliferation and differentiation of cells in these tissues, and mutations can lead to developmental disorders like aplasia of the lung....

SHISA4 (Shisa Family Member 4): SHISA4 is involved in the regulation of synaptic function and neuronal excitability. It modulates the activity of key receptors in the central nervous system, including AMPA and NMDA receptors, and is implicated in the regulation of neuronal signaling and plasticity. Its role in synaptic modulation makes it a gene of interest in the study of neurological disorders and synaptic dysfunctions....

Pine nuts, the edible seeds of pine trees, are a common ingredient in various cuisines and dishes. However, some individuals may experience pine nut intolerance, impacting their ability to consume pine nuts without discomfort....

Pistachio intolerance refers to adverse reactions or symptoms that some individuals may experience after consuming pistachio nuts. It differs from pistachio allergies as it does not involve the immune system's response to specific proteins but is related to difficulties in digesting certain components in pistachios....

FGF13 (Fibroblast Growth Factor 13): FGF13, a member of the fibroblast growth factor (FGF) family, operates at the crossroads of cellular growth and differentiation. This protein is a key orchestrator in the complex symphony of cellular processes, influencing cell development and differentiation. Its spotlight in the realm of neuroscience is well-established, where it contributes to the functioning of neurons. Researchers delve into the depths of FGF13's impact on neurological disorders, aiming to unlock its potential in understanding conditions that affect the brain and nervous system....

SHLD1 (Shieldin Complex Subunit 1): SHLD1 is a component of the shieldin complex, which plays a key role in DNA repair. It is involved in the repair of double-strand breaks, particularly in non-homologous end joining, a crucial process for maintaining genomic stability and preventing mutagenesis....

SHMT1 (Serine Hydroxymethyltransferase 1): SHMT1 catalyzes the conversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate, crucial for nucleotide synthesis and methylation reactions. Its function is vital for DNA replication and repair, impacting cell proliferation and genetic stability. SHMT1's role in folate metabolism links it to cancer risk and neurological disorders....

SHPRH (SNF2 Histone Linker PHD RING Helicase): SHPRH is a DNA helicase involved in the repair of DNA damage and the maintenance of genomic stability. It plays a critical role in the DNA damage response by facilitating the repair of DNA double-strand breaks, thereby preventing mutations that could lead to cancer. SHPRH has been identified as a tumor suppressor, with mutations in this gene associated with increased susceptibility to various cancers, highlighting its importance in protecting against genomic instability and tumorigenesis....

Plaice intolerance is a condition where individuals have difficulty digesting plaice, a type of flatfish, leading to gastrointestinal discomfort. This differs from a plaice allergy, which involves an immune system response and can cause more severe reactions. People with plaice intolerance typically experience digestive symptoms after consuming plaice....

SHQ1 (SHQ1, H/ACA Ribonucleoprotein Assembly Factor): SHQ1 is a crucial assembly factor for H/ACA ribonucleoproteins (RNPs), which are involved in the processing and modification of RNA. This includes the maturation of rRNA, snRNA, and the stabilization of telomerase RNA component (TERC). SHQ1 plays a vital role in the biogenesis of H/ACA RNPs, essential for proper cell function and maintenance of genomic stability. Disruptions in SHQ1 function can lead to defects in RNA processing and are implicated in various cellular dysfunctions....

FHIT (Fragile Histidine Triad Diadenosine Triphosphatase): FHIT is a tumor suppressor gene involved in purine metabolism. Loss or alteration of this gene has been linked to a variety of cancers, indicating its role in tumor suppression....

SORCS1 (Sortilin-Related VPS10 Domain Containing Receptor 1): SORCS1 is a gene that encodes a receptor involved in protein trafficking and sorting. It plays a role in the regulation of receptor signaling and may have implications in neural development and synaptic function. ..

FHOD3 (Formin Homology 2 Domain Containing 3): FHOD3 is a member of the formin family of proteins, which play a crucial role in the organization and regulation of the actin cytoskeleton. This protein is particularly significant in cardiac muscle and other tissues, where it facilitates the assembly of actin filaments, thereby influencing cell shape, adhesion, and motility. FHOD3's activity is pivotal during cell division, migration, and muscle contraction, contributing to the proper functioning of cardiovascular and skeletal systems. Its regulatory mechanisms involve the dynamic remodeling of the actin cytoskeleton, essential for heart development and function. Dysregulation of FHOD3 has been...

SORCS2 (Sortilin-Related VPS10 Domain Containing Receptor 2): SORCS2 is involved in neuronal development and signaling. It is a member of the VPS10 domain-containing receptor family, which plays roles in neurotrophic signaling and neural plasticity. Dysregulation of SORCS2 has been linked to neurological disorders, including Alzheimer’s disease and schizophrenia....

FIBIN (Fibin): FIBIN is a gene that encodes a protein involved in embryonic development, particularly in the development of the heart and blood vessels. It plays a role in signaling pathways that regulate cell differentiation and tissue morphogenesis. Mutations in FIBIN are implicated in developmental disorders....

SIDT1 (SID1 Transmembrane Family, Member 1): SIDT1 is involved in the cellular uptake of double-stranded RNA, playing a role in RNA interference and antiviral responses. It is significant in understanding cellular mechanisms for fighting viral infections and in the study of RNA-based therapeutic strategies....

SORCS3 (Sortilin-Related VPS10 Domain Containing Receptor 3): SORCS3 is a member of the VPS10 domain-containing receptor family and plays a role in protein trafficking and sorting within cells. It is particularly important in the nervous system, where it regulates the trafficking of proteins involved in synaptic function. Dysregulation of SORCS3 has been linked to neurological disorders, including Alzheimer's disease and schizophrenia....

FYB2 (FYN Binding Protein 2): FYB2, also known as ADAP2, is involved in signal transduction pathways within immune cells. It acts as an adaptor protein, mediating interactions between various signaling molecules, and plays a role in the regulation of immune cell activation and response. Its function is important for understanding the mechanisms of immune regulation and potential immune-related disorders....

SOS2 (Son of Sevenless Homolog 2): SOS2 is involved in cell signaling and the activation of the Ras/MAPK pathway. It serves as a crucial mediator in cellular responses to growth factors, cytokines, and extracellular signals, contributing to various physiological processes and cellular outcomes....

Plums, sweet and juicy fruits known for their delightful taste and vibrant colors, are enjoyed by many. However, some individuals may experience plum intolerance, impacting their ability to digest this fruit without discomfort. ...

Rutabaga, a root vegetable with a mildly sweet and nutty flavor, is used in a variety of culinary dishes, including soups, stews, and roasted vegetables. However, some individuals may experience rutabaga intolerance, impacting their ability to consume rutabaga without discomfort....

FKBP4, also known as FK506-binding protein 4 or FKBP52, is a member of the FK506-binding protein (FKBP) family, which are peptidyl-prolyl cis-trans isomerases (PPIases) that function as molecular chaperones. FKBP4 is primarily found in the cytoplasm and nucleus of cells and is involved in regulating protein folding, trafficking, and signal transduction. One of the primary functions of FKBP4 is its role as a co-chaperone for steroid hormone receptors, including the glucocorticoid receptor (GR) and androgen receptor (AR). FKBP4 interacts with these receptors in the cytoplasm, facilitating their proper folding and assembly into functional complexes with heat shock proteins (HSPs). Upon ligand...

FZD1 (Frizzled Class Receptor 1): FZD1 is a member of the frizzled receptor family, pivotal components of the Wnt signaling pathway. This pathway plays a central role in developmental processes, tissue regeneration, and cancer progression. FZD1, as a Wnt receptor, serves as a key player in modulating cellular responses to Wnt ligands, thereby influencing critical biological events and holding potential implications in disease mechanisms....

SIDT2 (SID1 Transmembrane Family Member 2): SIDT2 is involved in the cellular uptake of RNA molecules, playing a role in RNA interference (RNAi) mechanisms. It's important in the study of gene regulation and has potential implications in the development of RNA-based therapeutics. The function of SIDT2 in RNA transport is crucial for understanding how cells regulate gene expression and respond to external RNA molecules....

SOX2, short for SRY (Sex Determining Region Y)-Box 2, is a critical transcription factor that plays a pivotal role in embryonic development, stem cell pluripotency, and tissue homeostasis. Positioned predominantly within the nucleus of cells, SOX2 is involved in the regulation of gene expression by binding to specific DNA sequences and modulating the activity of target genes. One of the primary functions of SOX2 is its involvement in the maintenance of stem cell pluripotency and self-renewal. Alongside other transcription factors, such as OCT4 and NANOG, SOX2 forms a core regulatory network that sustains the undifferentiated state of embryonic stem cells and...

FZD10 (Frizzled Class Receptor 10): FZD10 is a receptor for Wnt signaling proteins, playing an essential role in embryonic development, cell proliferation, and differentiation. This gene is particularly involved in the Wnt/β-catenin signaling pathway and has been implicated in cancer development, especially in the context of abnormal Wnt signaling....

SOX4 (SRY-Box Transcription Factor 4): SOX4 is a transcription factor that plays a pivotal role in the regulation of embryonic development and cell fate determination. It is critical for the development of the heart, pancreas, and lymphocytes, as well as in the process of tumorigenesis. Overexpression of SOX4 has been implicated in the progression of several cancers, serving as a key regulator of cell proliferation, apoptosis, and metastasis, thus highlighting its dual role in development and cancer....

FZD4 (Frizzled Class Receptor 4): FZD4 is a gene that encodes a receptor for Wnt signaling molecules. The Wnt signaling pathway is essential for embryonic development, tissue homeostasis, and stem cell regulation. FZD4's role in this pathway makes it a key player in processes like cell fate determination and tissue regeneration....

FLG (Filaggrin): FLG encodes a protein crucial for skin barrier function. Mutations in FLG are strongly associated with skin conditions like atopic dermatitis (eczema) and can increase the risk of other allergic diseases....

SIGLEC1 (Sialic Acid Binding Ig-Like Lectin 1): Also known as sialoadhesin or CD169, SIGLEC1 is a member of the I-type lectins, recognizing sialic acid residues on cell surfaces. It is expressed primarily on macrophages and plays roles in cell-cell interactions, mediating binding to sialylated pathogens, and modulating immune responses. SIGLEC1 has been implicated in the regulation of immune surveillance and in the pathogenesis of infectious diseases and certain cancers....

SOX5 (SRY-Related HMG-Box Gene 5): SOX5 is a member of the SOX (SRY-related HMG-box) family of transcription factors, known for playing a pivotal role in the regulation of embryonic development and the determination of cell fate. It is involved in a wide range of biological processes, including the regulation of chondrogenesis, the development of the nervous system, and the differentiation of various cell types. SOX5 functions by binding to DNA and influencing the transcription of genes crucial for cell growth, development, and differentiation. Mutations or dysregulation of SOX5 have been implicated in diverse pathological conditions, such as developmental disorders and...

FLNB (Filamin B): FLNB encodes a protein that is crucial for the cross-linking of actin filaments in the cytoskeleton. Mutations in FLNB cause a range of skeletal disorders known as filaminopathies, which include conditions like spondylocarpotarsal synostosis syndrome and Larsen syndrome. These disorders are characterized by skeletal malformations and joint dislocations....

FZD8 (Frizzled Class Receptor 8): FZD8 encodes a receptor for Wnt signaling proteins, playing a pivotal role in embryonic development and cell signaling pathways. This gene is essential in various processes including cell differentiation, proliferation, and polarity. Abnormalities in FZD8 signaling are associated with developmental defects and various cancers....

SIK2 (Salt-Inducible Kinase 2): SIK2 is part of the AMPK family of kinases and is involved in energy homeostasis. It plays a role in the regulation of lipid and glucose metabolism and has been implicated in obesity, diabetes, and cancer metabolism....

Pomegranate, a vibrant and nutrient-rich fruit known for its sweet and tangy taste, is enjoyed in various culinary dishes and beverages. However, some individuals may experience pomegranate intolerance, impacting their ability to consume pomegranate without discomfort....

SOX6 (SRY-Box Transcription Factor 6): SOX6 plays a critical role in the development and differentiation of various tissues, including cartilage, muscle, and the central nervous system. It is essential for chondrocyte differentiation and skeletal development, and its expression levels are also crucial in the regulation of neuronal development and differentiation. Dysregulation of SOX6 has been implicated in various disorders, including skeletal malformations and potential impacts on cognitive function, reflecting its diverse roles in developmental processes....

SIM1 (Single-Minded Homolog 1): SIM1 is a transcription factor that plays a crucial role in the development of specific brain regions, including the hypothalamus. It is involved in the regulation of appetite and energy homeostasis. Mutations in SIM1 have been associated with obesity and other metabolic disorders....

G2E3 (G2/M-Phase Specific E3 Ubiquitin Protein Ligase): G2E3 is an E3 ubiquitin ligase that plays a role in cell cycle regulation, particularly in the G2/M phase transition. It is involved in the ubiquitination and degradation of cell cycle regulators, and its dysregulation can lead to cell cycle abnormalities and contribute to tumorigenesis....

SIPA1L3 (Signal-Induced Proliferation-Associated 1 Like 3): SIPA1L3 is a gene that plays a role in signal transduction and cellular proliferation. It is particularly important in the nervous system, where it contributes to synaptic regulation and neuronal signaling. Abnormalities in SIPA1L3 have potential implications in neurological disorders, possibly affecting cognitive functions and neurodevelopment....