HSV-2 IgG antibodies are produced by the immune system in response to Herpes Simplex Virus type 2, which is most commonly linked to genital herpes. A positive result indicates prior exposure to HSV-2, even if no symptoms have been experienced. These antibodies usually develop within several weeks after infection and persist long-term. The test identifies whether an individual has been infected at some point but cannot determine the timing or whether the virus is currently active.
Testing for HSV-2 IgG antibodies is advised for individuals experiencing recurrent genital symptoms, those with new sexual partners, or during pregnancy to evaluate the risk of transmission. It is also important for people undergoing IVF or immunosuppressive therapy, where latent infections may impact outcomes.
HSV-2 is primarily transmitted through sexual contact, including genital-genital, oral-genital, or anal-genital contact. The virus can be spread even when symptoms are not present, through asymptomatic viral shedding.
A positive result indicates that the immune system has produced antibodies against HSV-2, signifying a past infection. It does not indicate current infectivity or activity levels but confirms the presence of the virus in the body, which may be contagious at times.