p-Cresol Sulfate
p-Cresol sulfate is a metabolite produced by intestinal bacteria through the breakdown of the amino acid tyrosine. It is primarily detoxified in the liver and excreted by the kidneys. Higher levels may reflect increased bacterial protein fermentation, impaired detoxification, or reduced renal clearance. Balanced levels indicate efficient gut microbial metabolism and normal liver–kidney function.
Description
High levels may indicate increased bacterial protein fermentation, impaired liver detoxification, or reduced kidney clearance. Elevated p-Cresol sulfate is often seen in cases of gut dysbiosis or when liver–kidney detox pathways are under strain.
Testing can be beneficial for individuals experiencing chronic fatigue, digestive imbalances, or suspected detoxification challenges. It may also assist those with compromised kidney function, liver strain, or indications of microbial imbalance in the gut.
Levels depend on gut microbial composition, protein intake, and the body’s ability to conjugate and excrete metabolites through the liver and kidneys. Diets high in animal protein or poor microbial diversity can increase production.
Yes. Supporting gut health through fiber intake, antioxidants, and probiotics can help reduce bacterial overproduction. Enhancing liver detoxification and maintaining hydration support the clearance of p-Cresol sulfate through natural elimination pathways.
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