PITX2

PITX2 (Paired Like Homeodomain 2): PITX2 is a transcription factor that plays a vital role in the development of multiple organ systems, including the eyes, heart, and abdominal organs. It is involved in establishing the body’s left-right asymmetry. Mutations in PITX2 are associated with Axenfeld-Rieger syndrome, a condition affecting the eyes and other organs. Understanding PITX2 is essential for developmental biology and for exploring treatments for related congenital disorders.

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