Primary Bile Acids (CA, CDCA)
Primary bile acids – cholic acid (CA) and chenodeoxycholic acid (CDCA) – are synthesized in the liver and constitute the initial phase of bile acid metabolism. They play a crucial role in emulsifying dietary fats and aiding the absorption of fat-soluble vitamins. Elevated levels may indicate disrupted bile acid synthesis or cholestasis, whereas decreased levels can suggest diminished hepatic production or impaired bile flow. Balanced levels are indicative of normal liver function and bile acid metabolism.
Description
Increased levels of cholic acid (CA) and chenodeoxycholic acid (CDCA) may indicate impaired bile acid flow, cholestasis, or disrupted liver metabolism. Elevated concentrations can also occur due to inflammation, toxins, or hormonal imbalances affecting liver function.
Testing can be useful for individuals experiencing digestive discomfort after consuming fatty meals, bloating, or nausea, as well as for those suspected of having liver or gallbladder problems. It can also offer insights into the absorption of fat-soluble vitamins and the overall metabolism of bile acids.
Levels depend on liver synthesis, bile flow, microbial metabolism, and intestinal reabsorption. Hormonal changes, diet composition, medications, or gut dysbiosis can all affect bile acid balance and recycling.
Yes. Supporting liver and gallbladder health with proper hydration, fiber, and nutrient intake (especially choline, taurine, and antioxidants) promotes normal bile synthesis and flow. Regular physical activity and maintaining gut microbial balance also help optimise bile acid turnover.
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