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TIAM2
TIAM2, also known as T-lymphoma invasion and metastasis-inducing protein 2, is a crucial member of the TIAM family of guanine nucleotide exchange factors (GEFs). Predominantly found in the cytoplasm, TIAM2 plays an essential role in regulating cellular functions, particularly those related to cytoskeletal dynamics, cell migration, and invasion. A key characteristic of TIAM2 is its function as a molecular switch activating Rho GTPases, especially Rac1. By means of its GEF activity, TIAM2 promotes the exchange of GDP for GTP on Rac1, initiating downstream signalling pathways that govern actin cytoskeleton rearrangements.
Tests containing this item
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