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TMPRSS6 (Transmembrane Serine Protease 6): TMPRSS6 is a protein that plays a crucial role in regulating iron metabolism, primarily by controlling hepcidin — the hormone responsible for iron absorption. Mutations in TMPRSS6 can lead to iron-refractory iron deficiency anemia (IRIDA), a type of anemia that does not respond to oral iron supplementation.

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