IDO Activity (Tryptophan/Kynurenine ratio)

IDO (indoleamine 2,3-dioxygenase) activity indicates the rate at which the amino acid tryptophan is metabolised into kynurenine. This pathway is regulated by immune and inflammatory signals, especially cytokines like interferon-γ. Elevated IDO activity (manifested as a low tryptophan/kynurenine ratio) may signify immune activation, chronic inflammation, or oxidative stress. Balanced IDO activity reflects normal immune regulation and sufficient tryptophan availability for the synthesis of serotonin and melatonin.

No image found

Description

What does IDO activity indicate?

IDO (indoleamine 2,3-dioxygenase) activity indicates how actively the amino acid tryptophan is converted into kynurenine. This pathway is closely associated with immune regulation and inflammation, as it is triggered by cytokines such as interferon-γ.

What can increased IDO activity indicate?

Higher IDO activity (indicated by a lower tryptophan/kynurenine ratio) may signify immune system activation, persistent inflammation, infection, or oxidative stress. This implies that tryptophan is being rerouted from serotonin production to immune-related metabolic processes.

What can a reduced IDO activity indicate?

Low IDO activity (a higher tryptophan/kynurenine ratio) may indicate decreased immune activation or reduced inflammatory signaling. It can also imply sufficient tryptophan availability for serotonin and melatonin synthesis.

How can IDO balance be maintained?

Supporting balanced immune and inflammatory function is essential. Adequate antioxidant intake, stress management, and maintaining healthy gut and immune function can help normalize IDO activity. Ensuring sufficient dietary tryptophan alongside cofactors such as B vitamins and magnesium promotes optimal tryptophan metabolism.

Your Cart

Content
What does IDO activity indicate?
What can increased IDO activity indicate?
What can a reduced IDO activity indicate?
How can IDO balance be maintained?
What does IDO activity indicate?
What can increased IDO activity indicate?
What can a reduced IDO activity indicate?
How can IDO balance be maintained?
girl-img

Trusted by over 100.000+ customers

card-swiper-image
star-image

The home test was incredibly simple to use, with clear and easy-to-follow instructions. The results were precise and well-explained. I also appreciated the option to get my questions answered about the results.

Ramesh Kumar

card-swiper-image
star-image

I found the home test process seamless and hassle-free. The instructions were straightforward, and the results were presented in a very professional and clear manner. Having the chance to clarify my doubts made it even better.

Priya Sharma

card-swiper-image
star-image

Using the home test was a breeze. The directions were easy to understand, and the detailed results were shared promptly. It was comforting to know that I could ask questions about the results and get quick responses.

Amit Joshi

card-swiper-image
star-image

The home testing kit was simple to use, and the instructions were clear. The detailed report was very informative, and I felt reassured by the opportunity to discuss the results with a professional.

Meena Iyer

card-swiper-image
star-image

The home test was well-designed and came with clear, step-by-step instructions. The results were detailed and easy to interpret. I also appreciated being able to ask follow-up questions about my report.

Vikram Singh