SDMA (Symmetric Dimethylarginine)
SDMA is a methylated derivative of the amino acid arginine and is primarily excreted by the kidneys. Unlike ADMA, SDMA does not directly inhibit nitric oxide synthase but reflects similar metabolic and renal processes. Elevated SDMA levels can indicate reduced kidney clearance or altered amino acid metabolism. Stable or optimal SDMA values suggest efficient renal function and normal arginine turnover.
Description
Elevated SDMA levels may not directly cause noticeable symptoms but can indicate reduced kidney function or disrupted amino acid metabolism. Individuals might feel tired, retain fluids, or exhibit other signs linked to decreased renal clearance.
Testing SDMA is beneficial for anyone looking to evaluate kidney health, especially those with conditions such as hypertension, diabetes, or cardiovascular disease. It is also applicable for individuals on high-protein diets, taking supplements, or medications that could affect kidney function.
SDMA concentrations are influenced by kidney filtration rate, protein turnover, and methylation activity. Impaired renal clearance or increased arginine methylation can raise SDMA levels, while proper hydration and metabolic balance help keep these levels stable.
In many cases, supporting kidney and metabolic health can help normalize SDMA. Maintaining adequate hydration, managing blood pressure and blood sugar, and reducing oxidative stress are key. A balanced diet and supporting methylation pathways may also play a role in keeping SDMA within a healthy range.
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